Comparative genomic analysis of hepadnaviruses using GLUE
Welcome to Hepadnavirus-GLUE, an open resource for comparative genomic analysis of hepadnaviruses, developed using the GLUE software framework.
Hepadnaviruses (family Hepadnaviridae) are a diverse group of small, non-enveloped DNA viruses that infect a broad range of animal species. This family includes several pathogens of humans and domesticated animals, as well as viruses being developed for therapeutic uses.
GLUE is an open, integrated software toolkit designed for storing and interpreting sequence data. It supports the creation of bespoke projects, incorporating essential data items for comparative genomic analysis, such as sequences, multiple sequence alignments, genome feature annotations, and other associated data.
Projects are loaded into the GLUE "engine," forming a relational database that represents the semantic relationships between data items. This foundation supports systematic comparative analyses and the development of sequence-based resources.
Hepadnavirus-GLUE contains genome feature definitions, multiple sequence alignments, and annotated reference sequences for all hepadnavirus species included in the most recent ICTV report.
This Hepadnavirus-GLUE project can be extended with additional layers, openly available via GitHub, including Hepadnavirus-GLUE-EVE which extends Hepadnavirus-GLUE through the incorporation of endogenous hepadnaviral elements.
Please see the User Guide for more details.
Note: Those specifically interested in hepatitis B virus (HBV) may wish to investigate HBV-GLUE and NCBI-HBV-GLUE. This family of GLUE projects was developed specifically for HBV and incorporates a graphical user interface (GUI) (HBV-GLUE-WEB), which allows users to explore the HBV-GLUE database in a web browser. The University of Glasgow hosts a web instance of the GUI version of HBV-GLUE.
License
This project is licensed under the GNU Affero General Public License v. 3.0.